Синтез некоторых пиперидилпроизводных изохинолинов, [1,6]нафтиридинов и их N-замещенных в пиперидиновом фрагменте тема диссертации и автореферата по ВАК РФ 02.00.03, кандидат химических наук Ковальский, Дмитрий Анатольевич

• Ковальский, Дмитрий Анатольевич
• кандидат химических наук
• 2010

Оглавление диссертации кандидат химических наук Ковальский, Дмитрий Анатольевич

1. Введение.

2. Литературный обзор.

2.1 Методы синтеза 3-замещенных изохинолинов.

2.2 Методы циклизации пиридинового кольца, протекающего с замещением атома водорода.

2.3 Методы циклизации пиридинового кольца, протекающего без замещения атома водорода.

2.4 Методы получения изохинолинов, протекающие с образованием бензольного кольца.

2.5 Сравнение методов синтеза 3-замещенных изохинолинов.

3. Общая часть.

3.1 Синтез З-(З-пиперидил)- и 3-(4-пиперидил)изохинолинов.

3.2 Синтез 7-(3-пиперидил)- и 7-(4-пиперидил)-[1,6]нафтиридинов.

3.3 Синтез 7-(3-пиперидил)- и 7-(4-пиперидил)-[1,6]нафтиридин-5онов.

3.4 Синтез З-(З-пиперидил)- и 3-(4-пиперидил)-изохинолин-1-онов.

3.5 Превращения пиперидилнафтиридонов и изохинолонов.

3.5.1 Синтез 5-амино-7-пиперидилнафтиридинов и 1-амино-Зпиперид илизохинол инов.

3.5.2 Реакции построения С-С-связи с участием трифлатов пиперидилизохинолин-1 -онов.

3.6 Восстановление 7-(4-пиперидил)-[1,6]нафтиридин-5-онов.

3.7 Биологические испытания.

4. Выводы.

5. Экспериментальная часть.

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