Роль различных типов антиген-презентирующих клеток в регуляции апоптоза лимфоцитов и репликации ВИЧ-1 при ВИЧ-инфекции тема диссертации и автореферата по ВАК РФ 03.03.03, доктор медицинских наук Макарова, Маргарита Владимировна

• Макарова, Маргарита Владимировна
• доктор медицинских наук
• 2011

Заключение диссертации по теме «Иммунология», Макарова, Маргарита Владимировна

выводы

1. Репликация ВИЧ-1 в С04-лимфоцитах является результатом их межклеточных взаимодействий как с профессиональными, так и полупрофессиональными антиген-презентирующими клетками.

2. Ведущим фактором репликации ВИЧ-1 в лимфоцитах взаимодействующих с различными типами антиген-презентирующих клеток, являются лиганд-рецепторные взаимодействия.

3. Репликация ВИЧ-1 в лимфоцитах, взаимодействующих с эндотелиальными клетками, не сопровождается появлением классических признаков их активации и пролиферации.

4. Эндотелиальные клетки индуцируют устойчивость к апоптозу продуктивно инфицированных лимфоцитов, в то время как профессиональные антиген-презентирующие клетки (дендритные клетки и макрофаги) не обладают данной способностью.

5. Устойчивость продуктивно инфицированных лимфоцитов к апоптозу обусловлена их лиганд-рецепторными межклеточными взаимодействиями с эндотелиальными клетками.

6. Способность эндотелиальных клеток инициировать репликацию ВИЧ-1 в лимфоцитах является результатом экспрессии в инфицированных клетках вирусного белка Nef. Дендритные клетки и макрофаги инициируют репликацию ВИЧ-1 в лимфоцитах Nef-независимым путем.

7. Устойчивость к апоптозу у продуктивно инфицировнных лимфоцитов, взаимодействующих с эндотелиальными клетками, обусловлена вирусным белком Nef.

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