Исследование генерализованного метаболического ответа нервных клеток на смену функционального состояния и на действие повреждающих факторов тема диссертации и автореферата по ВАК РФ 03.00.02, доктор биологических наук Гордон, Рита Яковлевна

• Гордон, Рита Яковлевна
• доктор биологических наук
• 2000

Оглавление диссертации доктор биологических наук Гордон, Рита Яковлевна

Оглавление

1. Введение 3

2. Литературный обзор 6

3. Материалы и методы 58

4. Результаты и обсуждение • 62

Распад и накопление рибосом в цитоплазме при изменениях функционального состояния

Ультраструктурный анализ состояния ядрышка

Ультраструктурный анализ цитоплазмы

Исследование состояния рРНК в рибосомах

Изменение /*Гапри смене функционального состояния животных и при действии повреждающих факторов

Изменение Кр при смене функционального состояния животных и при действии повреждающих факторов

Список литературы диссертационного исследования доктор биологических наук Гордон, Рита Яковлевна, 2000 год

1. Насонов Д.Н. (1959): Местная реакция протоплазмы и распространяющее возбуждение. М. - Л., 434 с.

2. Незвецкий B.C., Бусыгина С.Г., Березин В.А., Дворецкий А.И. (1990): ЦНС-синдром. Характеристика промежуточных филаментов головного мозга крысы. Радиобиология, т.ЗО, 243-246.

3. Палладии A.B. (1965): Вопросы биохимии нервной системы. Наукова думка, Киев, 185 с.

4. Певзнер Л.З. (1972): Функциональная биохимия нейроглии, Наука, Л., 198 с.

5. Питере А., Палей С., Уэбстер Г. (1972): Ультраструктура нервной системы, Мир, Москва., 175 с.

6. Поглазов Б.Ф. (1981): Немышечнще сократительные белки. 'Немышечные двигательные системы, М., 3-13.

7. Попова Н.К. (1986): Серотонин и зимняя спячка. В кн.: Эволюционные аспекты гипобиоза и зимняя спячка, Ленинград, Наука, 25-31

8. Попова НК., Лобачева И.И., Карманова И.Г., Шиллинг Н.В. (1982): Ж. эвол. биохим. ифизиол., Т. 18, 430-432.

9. Промыслов М.Ш., Баскаева Т.С. (1977): Регуляция активности моноаминоксидазы мозга при черепно-мозговой травме. В кн.: Вопросы нейрохимии, 141-146.

10. Протас А.Ф. (1997): Характеристики репарации ДНК в нейронах головного мозга крыс после низких доз гамма-радиации, Радиац. Биол. Радиоэкол., 37:3, 320-323.

11. Протас А.Ф.: Действие низких доз внешней и внутренней радиации на синтез ДНК, РНК и белков в клетках коры мозга, Укр. Биохим. Ж., 1995 67 105-109

12. Свиткина Т.М., Васильев Ю.М. (1986): Изменение цитоскелета мышиных эмбриональных фибробластов. Электронномикроскопические исследования платиновых реплик. Цитология, т.25, 1004-1012.

13. Семешина Т.М., Певзнер Л.З. (1975): Влияние зимней спячки и пробуждения на содеохание цитоплазматической РНК в нейронах головного и спинного мозга краснощеких сусликов. Цитология, т.75, 353-358.

14. Спирин A.C. (1986): Молекулярная биология. Структура рибосомы и биосинтез белка, Высшая школа, Москва, 303 С.СПИСОК ЛИТЕРАТУРЫ

15. Силина А.Г., Свердлов А.Г. (1987): Влияние сверхвысоких доз у-радиации на содержание и обмен серотонина в головном мозге крыс. Радиобиология, т.27, 556558.

16. Скибо Г.Г., Березовская O.JL (1987): Цитоскелет нервных клеток в процессе их дифференцировки. Нейрофизиология, т. 19, 558-565.

17. Стивене Ч. (1982): Нейрон. В кн.: «Мозг», Москва, «Мир», 31-57.

18. Тодоров И.Н., Смалько П Я., Галкин А.П. (1977): Состояние полирибосом как отражение функционального взаимодействия систем трансляции и транскрипции в прроцессе восстановления биосинтеза белка, ингибированногог циклогексимидом. Биохимия, 42., 2149-2159.

19. Хандбабян М.И., Параманукян А.К. (1980): Влияние стимуляции норадренергической системы ствола на включение 3Н-уридина в различные структуры мозга. Физиол. журнал СССР, т. 66, 350-353.

20. Челидзе П .В, Зацепина О. В. (1988): Морфофункциональная классификация ядрышек. Цитология 105:, 252-268.

21. Черкасова Л.С., Тайц М.Ю. (1977): Реакция гипоталамуса и состояние биоэнергетических процессов в головном мозгу при хроническом воздействии ионизирующей радиации. В кн.: Вопросы нейрохимии, 122-129.

22. Чирков Р.П., Бойков П.Я., Дружинина М.И., Тодоров М.Н. (1983): Деградация 18S и 28S рибосомальных РНК в цитоплазме клеток печени крыс при подавлении синтеза белков. Биохимия, т.48, 1157-62.

23. Штарк М.Б. (1970.): Мозг зимнеспящих. Наука, Новосибирск, 240 с.

24. Adolph K.W. (1980): Organization of chromosomes in HeLa cells: isolation of histone-depleted nuclei and nuclear scaffolds. J. Cell Sci., v.42, 291-304.

25. Agutter P.S. (1991): Review. Role of the cytoskeleton in nucleoplasm^ RNA and protein distributions. Biochem. Soc. Trans., v. 19, 1094-8.

26. Alberts В., Bray D., Lewis J., Raff V., Roberts K., and Watson J. (1994): Molecular biology of the cell, Garward Publishing Inc., New York & London.

27. Andersen P., Bland В., Dudar J.D. (1973): Organization of the hippocampal output. Exptl BrainRes., v. 17, 152-158.

28. Andreasen M., Lambert J.D.C., Skovgaard J.M. (1988): Effects of new non NMDA antogonistsl in the rat in vitro hippocampus. J. Physiol, v.403, p. 57.СПИСОК ЛИТЕРАТУРЫ

29. Andres КН. (1961): Untersuchung uber den feinlau von spinalganglien. Z. Zellforsch., Bd 55, 1: 1-48.

30. Arends M.J., Morris R.G., and Wylie A.H. (1990): Apoptosis. The role of the endonuclease. American Journal'of Pathology, 136, 593-608.

31. Arrigo A., Fakan S., Tissieres A. (1980): Localization of the heat-shock induced proteins in Drosophila melanogaster tissue culture cells. Develop. Biol, v.78, 86-103.

32. Ashburner M., Bonner J.J. (1979): The induction of gene activity in Drosophyla by heat shock (review). Cell, v. 17, 241-54.

33. Babity J.M., Armstrong J.N., Plumier J.C., Currie R.W., Robertson H.A. (1997): A novel seizure-induced synaptotagmin gene identified by differential display. PNAS USA, 1997 Mar 18; 94(6): 2638-41

34. Backendorf C., Overbeek G.P., van Boom J.H., et al. (1980): Role of 16S RNA in ribosome messenger recognition. Eur. JBiochem, v. 110, 599-604

35. Bakin A.V., Borisova O F., Shansky I.N., Bogdanov A.A. (1991): Spasial organization of template polynucleotides on the ribosome determined by fluorescence methods. JMol Biol, v. 221,441-453

36. Barra H.S., Arce C.A., Caputo R. (1980): Total tubulin and its aminoacylated forms during the development of the brain . Eur. J. Biochem., v. 109, 439-46.

37. Bassant M. H. and Court L. (1978): Effects of whole-body у irradiation on the activity of rabbit hippocampal neurons. Radiat. Res., 75, 593-606.

38. Bassel G. and Singer R.H. (1997): RNA and cytoplasmic filaments, Curr. Opin Cell Biol, v.9, 109-115.

39. Baudin F., Mougel M., Romby P., et al. (1989): Probing the phosphates of the Escherichia coli ribosomal 16S RNA in its naked form, in the 30S subunits and in the 70S ribosome. Biochemistry, v. 28, 5847-5855

40. Bauer C., Traub P. (1995): Interaction of intermediate filaments with ribosomes in vitro. Eur. J. Cell Biol., v. 68, 288-96.

41. Bauer K.D., Dethlefsen L.A. (1980): Total cellular RNA content correlation between flou cytometry and ultraviolet spectroscopy. J. Hisiochem Cytochem., v.28,493-498.

42. Beck S.C. and De Maio A. (1994): Stabilization of protein synthesis in thermotolerant cells during heat shock, J. Biol. Chem., 209, 21803-21811.СПИСОК ЛИТЕРАТУРЫ

43. Bell J., Nelson L., Pellegrini M. (1988): Effect of heat shock on ribosome synthesis in Drosophyla melanogaster. Mol Cell Biol., v. 8, 91 -95.

44. Becman A.L., Llados-Eckman C., Stanton T.L. (1992): Reduction of hibernation bout duration by intraventricular infusion of met-enkephalin. Brain Res., v.588, 159-163.

45. Bell J., Nelson L., Pellegrini M. (1988): Effect of heat shock on ribosome synthesis in Drosophyla melanogaster. Mol Cell Biol., v. 8, 91-95.

46. Benjamin I.J., Kroger В., Wieliams R.S. (1990): Activation of the heat shock transcription factor by hypoxia in mammalian cells. PNAS USA, . v. 87, 6263-67.

47. Bernelly-Zazzera A., Bassi M., Cassi E. (1959): The metabolism of isolated cerebral cortex from hypoxic rats. Exptl. Cell Res., 18, 3, 554-559.

48. Berthold W., Lim L. (1976): The metabolism of high-molecular-weith ribonucleic acid including polyadenylated species in the developing rat brain. Biochem.J. v. 154, 517-527.

49. Bernhardt R., Matus A. (1984): Light and electronmicroscopic studies of the distribution of microtubule-assotiated protein 2 in the rat brain: a difference between dendritic and axonal cytosceletons. J. Сотр. Neurol., v.226, 203-221.

50. Binger L.J., Frankfurder A., Kim H., et al. (1984): Heterogenety of microtubule-associated protein 2 during rat brain development. PNAS USA, v.81, 5613-17.

51. Bitting L., Suten E.L., Watson F.L., et al. (1994): C-fos mRNA increases in the ground squrrel suprachiasmatic nucleus during arousal from hibernation, Neurosci Lett., 3, 165 (12), 117-121.

52. Bitting L., Watson F.L., O'Hara B.F., Kilduff T.S., Heller H.C. (1999): HSP70 expression is increased during the day in a diurnal animal, the golden-mantled ground squirrel Spermophilus lateralis. Mol. Cell Biochem., v. 199, 25-34.

53. Black A.B., Subject J.E. (1989): Involvement of rRNA synthesis in the enhanced survival and recovery of protein ynthesis seen in thermotolerance. J. Cell Physiol, 138.; 439-449.

54. Blose S.H., Metzer D.J., Feramisco J.R. (1984): 10-nm Filaments are induced to collapse in living cells microinjected with monoclonal and polyclonal antibodies againts tubulin. J. Cell Biol, v.98, 847-58.

55. Bocharova L.S., Borovyagin V.L., Dyakonova T.L., Warton S.S., Veprinsev B.N. (1972): infrastructure and RNA synthesis in molluscan gliant neuron under electrical stimulation. Brain Res., 36: 371-384.СПИСОК ЛИТЕРАТУРЫ

56. Bonneau А.М., Darveau A., Sonenberg N.J. (1985): Effect of viral infection on host protein synthesis and rnRNA association with the cytoplasmic cytoskeletal structure. J Cell Biol., Apr; 100(4): 1209-1218.

57. Borer R.A., Lehren C.F., Eppenberger H.M., Nigg E.A. (1989): Major nucleolar proteins shuttle between nucleus and cytoplasm. Cell, 56(3): 379-390.

58. Bourgim N., Kabine M., Elkebbaj M.S. (1997): Characterization of opioid peptides and opioid receptors in the brain of jerboa (Jaculus orientalis), a hibernating rodent. Brain Res. Bull., v.44, 615-620.

59. Bournias N., Yardiabasis N., Buzin C., Flores J. (1990): Differential expression of heat shock proteins in Drosophila embryonic cells following metal ion exposure. Exp. Cell Res., v. 189, 177-182.

60. Brizzee K.R., Ordy J.M., Kaack M.B., and Beavers T. (1980): Effect of prenatal ionizing radiation on the visual cortex and hippocampus of newborn squirrel monkeys. J. Neuropathol. Exp. Neurol., 39, 523-540.

61. Brostrom N.A., Lin X., Cade Ch., Dmiljter D., Brostrom Ch. (1989): Loss of a calcium requirement for protein synthesis in pituitary cells following thermal or chemical stress. J. Biol Chem., v. 164, 1639-1543.

62. Brown I.R., Rush S.J. (1990): Expression of heat shock (hsp70) in the mammalian brain: Distinguisting constitutively expressed and hyperthermia-inducible mRNA species. J. Neurosci Res., v.25, 14-19.

63. Burgoyne R.D. (1986): Microtubule proteins in neuronal differentiation. Сотр. Biochem. and Physiol. Ser. В., v. 119, 129-149.

64. Caizergues-Ferrer M., Bouche G., Banville D., Amalric F. (1980): Effect of heat shock on RNA-polymerase activities in Chinese hamster ovary cells. BBRC, 97, 538-545.

65. Cajal R.S. (1955): Studies on the Cerebral Cortex (Limbic structures), London: Lioyd-Luke.

66. Cao Y., Wilcox K.S., Martin C.E., et al. (1996): Presence of mRNA for glutamic acid decarboxylase in both excitatory and inhibitory neurons. PNAS USA, v.93, n. 18, 9844-49.СПИСОК ЛИТЕРАТУРЫ

67. Chen K.D., Chu J.J., Lai Y.K. (1996): Modulation of protein ophosphorylation and stress protein expression by okadaik acid onheat shock cells. J. Cell Biochem., v. 61, 25565.

68. Chen J., Gracham S.H., Zhu R.L., Simon R.P. (1996): Stress proteins and tolerance to focal cerebral ischemia. J. Cereb Blood Flow Metab., 16, 566-77.

69. Chiu S.V., Oleinick N.L., Friedman L.R., and Stambrook P J. (1982): Hipersensitivity of DNA in transcriptionally active chromatin to ionizing radiation. Biochimica and Biophysica Ada, 699, 15-21.

70. Chook Y.M., Blodel G. (1999): Structure of the nuclear transport complex karyopherin-beta2-Ran x GppNHp. Nature, 20, 399:6733, 230-237.

71. Chou Y.-H., Skalli O., Goldman R.D. (1997): Intermediate filaments and cytoplasmic networking: new connections and more functions. Curr. Opin Cell Biol., v.9, 49-53.

72. Clark G.D. (1989): Role of excitatory amino acids in brain injury caused by hypoxia-ischemia, status epilepticus, and hypoglycemia. Clin Perinatol, 16(2): 459-74.

73. Clark G.D., Rothman S.M. (1987): Blokade of exitatory amino acid receptors protects anoxic hippocampal slices. Neurosci., v.21, n.3, 665-671.

74. Clarke D.J. (1985): Cholinergic innervation of the rat dendate hyrus: an immunocytochemical and electron microspectral study. Brain Res., V.360, 349-354.

75. Cohen M.M. (1973): Biochemistry in Cerebral Anoxia, Hypoxia and Ischemia. In: «Biochemistry, ultrastructure and physiology of cerebral anoxia, hypoxia and ischemia», ed. by Cohen M.M. and Karger S., 1-49.

76. Collier N.C., Schlesinger M.J. (1986): The dynamic state of heat shock proteins in chicken embryo fibriblasts. J. Cell Biol., v. 103, 1495-1507.

77. Core L.C., Strenberger N.H., Strenberger L.A., Casanova M.F., Struble R.G., Price D.L. (1986): Phosphorylated neurofilament antigents in neurofibrillary tangles in Alzheimer's dieses. J. Neuropathol Exp. Neurol, v.45, 56-64.

78. Cosgrove J.W., Heikkila J.J., Marks A., Broun I.R. (1983): Synthesis of S100 protein on free and membrane-bound polysomes of the rabbit brain. J. Neurochem., v. 40, 806-13.

79. Cui Y., Lee T.F., Wang L.C. (1996): State-dependent changes of brain endogenous opioids in mammalian hibernation. Brain Res Bull., v. 40, 129-133.СПИСОК ЛИТЕРАТУРЫ

80. Cui Y., Lee T.F., Westly J., Wang L.C. (1997): Autoradiographic determination of changes in opioid receptor binding in the limbic system of the Columbian ground squirrel at different hibernation states. Brain Res., v. 747, 189-194.

81. Cupello A., Patrone A., et al. (1993): Electric shock convulsions in the rabbit and brain cortex, GABA receptor function. Neurochem. Res., v. 18, 883-886.

82. Darzynckiewicz Z. (1979): Acridine orange as a molecular probe in studies of nucleic acids in situ. In Flow Cytometry and Sorting (Melamed M.R., Mullaney P. and Mendelson M.L. Eds.), John Wiley & Sons, New York, pp. 285-316.

83. Darzynkiewicz Z., Evenson D., Staino-Coico L., Sharpless Т., Melamed M.R. (1979): Correlation between cell cycle duration and RNA content. FN AS USA, v. 76, 358-362.

84. Darzynkiewicz Z., Kapuscinski J., Traganos F., Crissman H.A. (1987): Application of pyronin Y (G) in cytochemistry of nucleic acids. Cytometry, v. 8, 138-145.

85. Darzynkiewicz Z., Traganos F., Sharpless Т., Melamed M.R. (1975): Conformation of RNA in situ as studied by by acridine orange staining and automatic cytofluorometry. Exp. Cell Res., v.95, 143-153.

86. Darzynkiewicz Z., Traganos F., Sharpless Т., and Melamed M.R. (1975): Thermal denaturation of DNA in situ as studied by acridine orange staining and automatic cytofluorimetry. Exptl. Cell Res., 90, 411-428.

87. Davies S.N., Collingringe G.L. (1989): Role of excitatory amino acid receptors in synaptic transmission in area CA1 of rat hippocampus. Proc. Roy. Soc. London., v. 236, 373-384.

88. Descarries L., Gisiger V., Steriade M. (1997): Diffuse transmission by acetylcholine in the CNS. Progr. Neurobiol., v.53, n5, 603-625.

89. Dimberg Y., Vazqez M., Soderstrom S., Ebendal T. (1997): Effects of X-irradiation on nerve growth factor in the developing mause. Toxicol Lett, 15, 90, 1,35-43.

90. Dokas L.A. (1983): Analysis of brain and pituitary RNA metabolism: a review of recent methodologies. Brain Res. Rev., v. 5, 177-218.

91. Douwas A.S., Harrington С.А., Bonner J. (1975): Major nonhistone proteins of rat liver chromatin: Preliminary identification of myosin, tubulin, and tropomyosin. PNAS USA, v. 72, 3902-3906.

92. Dumbar T.S., Gentry G.A., Olson M.J. (1989): Interaction of nucleolar phosphoprotein B23 with nucleic acids, Biochemistry, 28, 9495-9501.

93. Dunn A. (1971): Brain protein synthesis after electroshock. Brain Res., v.35, 254-259.

94. Dwyer B.E., Nishimura R.N. (1992): Heat shock proteins in hypoxic-ischemic brain injiury: a perspective. Brain Pathol, v.2 (3), 245-51.

95. Eichle D.C. and Craig N. (1994): Processing of eucaryotic ribosomal RNA. Progress in Nucleic Acid Research and Molecular Biololy, 49, 197-239.

96. Engel J., Morrell Ir., Morrell F. (1970)|: Turnover of RNA in normal and secondarely epileptogenic rabbit cortex. Exptl. Neurology, v.26, 221-238.

97. Eremenko Т., Volpe P. (1975): Polysome translational state during the cell cycle. Eur. J. Biochem. v.52, 203-210.

98. Escande-Geraud M.L., AzumM.C., Tichadou J.L., Gas N. (1985): Correlation between rRNA transcription and distribution of a 100 kD nuclear protein in CHO cells. Exp. Cell Res., v. 161, 353-363.

99. Falkner F.G., Sanweber H., Bissman H. (1981): Two Drosophila melanogaster proteins related to intermediate filament proteins of vertebrate cells. J.Cell Biol., v.91, 175-81.

100. Feinendegen L.E., Bond V.P., Booz J., and Muhlensiepen H. (1988): Biochemical and cellular mechanisms of low-dose effects. International Journal Radiation Biology, 53, 2327.

101. Ferrer I., Planas A.M. (1995): Induction of heat-shock protein following systemic kaenate injection in the rat: evidence of protein axonal transport. Neuroscience, v. 69, 11118.

102. Fischer D.Z., Chaudhary N., Blodel G. (1986): CDNA sequencing of nuclear lamins A and G reveals primary an secondary structural homology to intermediate filament proteins PNAS USA, v.83, 6450-6454.

103. Fisher R.S., Levine M.S. (1989): Transmitter cosynthesis by corticopetal basal forebrain neurons. Brain Res., v.491, nl, 163-168.

104. Foisner R., Wiche G. (1991): Intermediate filament-assosiated proteins. Curr. Opin. Cell Biol., v.3, 75-81.СПИСОК ЛИТЕРАТУРЫ

105. Frerichs K.U., Smith С.В., Brenner М. et al. (1998): Supression of protein synthesis in brain during hibernation involves inhibition of protein initiation and elongation. PNAS USA, v.95, 14511-14516.

106. Frietsch M., Wu C. (1999): Phosphorylation of drosophila heat shock transcription factor, Cell stress and chaperones, 4, 102-117.

107. Fucuda J., Kateuama M., Jamaguchi K. (1981): Breakdoun of cytosceletal filaments selectively reduced Na and Ca spikes in cultured mammalian neurones. Nature, v. 294, 8285.

108. Fulton A.B. (1993): Spatial organization of the synthesis of cytoskeletal proteins. J. Cell Biochem., v. 52, 148-52.

109. Furano A.V., Bradley D.F., Chiders L.G. (1966): The conformation of the ribonucleic acid in ribosomes. Dye stacking studies. Biochemistry, v.5, 3044-3056.

110. Furuta S., Ohata S., Natakeyama Т., Nakamura K., Sakaki S. (1993): Recovery of protein synthesis in tolerance-induced hippocampal CA1 neurons after transient forebrain ischemia. Acta neuropathol. (Berl), v.86, 329-36.

111. Gall C. (1988): Seizures induce dramatic and distinctly different changes in enkephalin, dynorphin, and CCK immunoreactivities in mouse hippocampal mossy fibers./. Neurosci., v.8., 1852-1862.

112. Gangloff H. (1962): Acute effects of X irradiation on brain electrical activity in cats and rabbits. In: Effects of Ionizing Radiation on the Nervous System, pp. 123-135, International Atomic Energy Agency, Vienna.

113. Gardiol A., Racca C., Triller A. (1999): Dendritic and postsynaptic protein synthetic machinery. J Neurosci., 19: 168-79.

114. Gass P., Puop P., Klessung M. (1995): Correlation between seizure intensity and stress protein expression after limbic epilepsy in the rat brain. Neuroscience, v.65, 27-36

115. Gilby K.L., Armstrong J.N., Currie R.W., Robertson H.A (1997): The effects of hypoxia-ischemia on expression of c-Fos, c-Jun and Hsp70 in the young rat hippocampus. Brain Res Mol Brain Res, 48: 87-96.

116. Glover C.V. (1982): Heat shock induced rapid dephosphorilation of a ribosomal protein inDrosophyla. PNAS USA, v. 79, 1781-1785.

117. Gray E.G. (1975): Synaptic fine structure and nuclear, cytoplasmic and extracellular networks. J. Neurocytol., v.3, 315-339. jСПИСОК ЛИТЕРАТУРЫ

118. Greenberg М.Е., Ziff Е.В., Green L. (1986): Stimuation of neuronal acetylcholine receptors induced rapid gene transcription, Science, v.234, 80-83.

119. Greenberg J.R. (1981): The polyribosomal mRNA-protein complex is a dynamic structure. PNAS USA, v.78, 2923-2926. |

120. Gritti I., Mainville L., Jones BE. (1993): Co distribution of GABA with acetylcholinesynthesizing neurons in the basal forebrain of the rat. J. Сотр. Neurol., v.329, 438-457.

121. Gurdjian E., Stone W., Webster V. (1944): Cerebral metabolism in hypoxia. Arch. Neurol. Psychiatr., 51, 5, 472-477.

122. Guttman S., Glozer C., Alis C., Gorovsky M. (1980): Heat shock deciliation and release from anoxia, induced the synthesis at the same set of polypeptides in starved T. pyriforms. Cell, v. 22, 299-307.

123. Haak L.L., Mignot E., Kiiduff T.S., Dement W.C., Heller H.C. (1991): Regional changes in central monoamine and metabolite levels during the hibernation cycle in the golden-mantled ground squirrel. Brain Res., 563(1-2): 215-20.

124. Hadjiolov A.A. (1985): The Nucleolus and Ribosome Biogenesis. Cell Biology Monographs. Vol. 12, Springer-Verlag, Wien-NewYork, 268 pp.

125. Haley T.J. (1962,: Changes induced in brain activity by low doses of X irradiation. In: Effects of Ionizing Radiation on the Nervous System,. International Atomic Energy Agency, Vienna, pp. 171-185

126. Ham A.W. and Cormack D.H. (1979): Histology, Vol.1. J. B. Lippincott Company, New York.

127. Hardesty В., Odon O.W., Picking W. (1992): Ribosome function determined by fluorescence. Biochemie, v.72, 391-401.

128. Harris H., Watkins J.F., Ford C.E., Schoefl G.J. (1966): Artificial heterokaiyons of animal cells from different species. J. Cell Sci., v.l, 1-30.

129. He D.C., Nickerson J.A., Penman S. (1990): Core filaments of the nuclear matrix. J. Cell Biol., v. 110, 569-80.

130. He DC., Martin Т., Penman S. (1991): Localization of heterogeneous nuclear ribonucleoprotein in the interphase nuclear matrix core filaments and on perichromosomal filaments at mitosis. PNAS USA, v. 88, 7469-73.СПИСОК ЛИТЕРАТУРЫ

131. Heacock C.S., Broun Sh.L., Bamburg J.R. (1982): In vitro inactivation of actin by heat. Nat. Cancer Inst. Monograph., v.61, 73-75.

132. Heller H.C. (1979): Hibernation: Neuronal aspects. Annual Revew of Physiology, 40, 305-332.

133. Hesketh J.E. (1996): Sorting of messenger RNAs in the cytoplasm: mRNA localization and the cytoskeleton. Exp. Cell Res., v.225,: 219-36.

134. Hesketh J.E., Campbell G.P., Reeds P.J| (1986): Rapid response of protein synthesis to insulin in 3T3 cells: effects of protein kinase С depletion and differences from the response to serum repletion. BiosciRep., 6(9): 797-804

135. Hesketh J.E., Pryme I.F. (1991): Interaction between mRNA, ribosomes and the cytoskeleton. Biochem. J., v.277, 1-10.

136. Heydon W.E., Nguyen K.Q., Creed G.J., Jacobowitz D.M. (1985): Effect of reduction of cholinergic input on the consentration of specific proteins in different cortical regions of the rat brain, Brain Res, 29, 339, 2, 209-218.

137. Higashi Т., Nakai A., Uemura Y., Kikuchi H, Nagata K. (1995): Activation of heat shock factor 1 in rat brain during cerebral ischemia or after heat shock. Brain Res. Mol Brain Res., 32, 262-270

138. Higashi Т., Takechi H., Uemura Y., Kikuchi H., Nagata K. (1994): Differential induction of mRNA species encoding several classes of stress proteins following focal cerebral ischemia in rats. Brain Res., 650, 239-48.

139. Hightower L.E. (1991): Heat shock, stress proteins, chaperones, and proteotoxicity. Cell, v.66, 191-197.

140. Hirokawa N. (1986): Quick-freeze, deep-etch visualization of the axonal cytoskeleton. Trends Neurosci., v. 9, 67-71.

141. Hof P.R., Rosental R.E., Fiskum G. (1996): Distribution of neurofilament protein and calcium-binding proteins parvalbumin, calbindin, and calterin in the canine hippocampus. J. Chem Neuroanat, v. 11, 1-12.СПИСОК ЛИТЕРАТУРЫ

142. Hirsch С. A., Hiatt Н.Н. (1966): Turnover of liver ribosomes in fed and fasted rats. J. Biol Chem., 241: 5936-5946.

143. Hokfelt Т., Holets V.B., Staines W., et al. (1986): Coexistence of neuronal messengers -an overview Progr. Brain Res., v.68, 33-70.

144. Hopkins D.A., Plumier J.C., Currie R.W. (1998): Induction of the 27-kDa heat shock protein (Hsp27) in the rat medulla oblongata after vagus nerve injury. Exp Neurol., v. 153, 173-183.

145. Horrigan D.J., Horwitz B.A., Horowitz J.M. (1997): Serotonergic modulation of hippocampal cells in euthermic, cold-acclimated, and hibernating hamsters. Am. J Physiol., v.273, R1291-1298.

146. Hovland R., Hesketh J.E., Pryme I.F. (1996): The compartmentalization of protein synthesis: importance of cytoskeleton and role in mRNA targeting. Int. J. Biochem. Cell Biol, v. 28, 1089-1105.

147. Hovland R, Campbell G., Pryme I.F., Hesketh J.E. (1995): The mRNAs for cyclinA, c-myc,and ribosomal proteins L4 and S6 are associated with cytosceletal-bound polysomes in HepG2 cells. Biochem. J., v.310, 193-196.

148. Howe J.G., Hershey J.W. (1984): Translational initiation factor and ribosome association with the cytoskeletal framework fraction from HeLa cells. Cell., 37(1): 85-93.

149. Hugle В., Scheer U., Franke WW. (1985): Ribocharin: a nuclear M, 40000 protein specific to precursor particles of the large ribosomal subunit. Cell, 41, 615-627.

150. Hyden H. (1960): The neuron, The Cell, Eds. J. Brachet and A. Mirsky: Acad. Press, N-Y-L, 1-4 !t

151. Inagaki ML, Matzuoka Y., Ando S., et al. (1995): Dynamic property of intermediate filaments: regulation of phosphorylation, Bioessays, v. 18, 481-487.

152. Izaurraide E., Mattaj I.W. (1995): RNA export. Cell, v. 81, 153-159.

153. Jaberaboansari A., Nelson G.B., Roti Roti J.L., Wheeler K.T. (1988): Postradiationalterations of neuronal chromatin structure. Radiat. Res., 114, 94-104.

154. James S.J. and Makinodan T. (1988): T-cell potentiation in normal and autoimmuneprobe mice after extended exposure to low doses of ionizing radiation and/or caloric restriction. Int. J. Rad. Biol., 53, 137-152.

155. Jorgensen M.B., Johnsen F.F., Diener N.H. (1991): Post-ishemic and acid-induced c-fos protein expression in the rat hippocampus. Acta Neurol Scand, 84 (4), 352-356.

156. Johannessen A.J., Pyrme I.F., Vedeler A. (1995): Changes in distribution of actin mRNA in different polysome fractions following stimulation of MPC-11 cells. Mol. Cell Biochem., v.142, 107-115.

157. Jones K.J. and Lavelle A. (1986): Differential effects of axotomy on immature andmature hamster facial neurons: a time courts study of initial nucleolar and nuclear changes.1Journal of Neurocytology, 15: 197-206.

158. Jover T., Massrien A., Can P, Martin M.F., Conranol P. (1988): The correlation between Na channal subunit and scorpion toxin binding sites . J. Biol. Chem., v. 263, 15421548.

159. Kao H.T., Chafoori S., Porton B., Wong D.L. (1996): Brain specific proteins binding to the 3' HTR of the 5-HT2c receptor mRNA. Brain Res. Mol. Brain Res., v.31, 174-84.

160. Kato H., Liu Y., Kogure K, Kato K. (1994): Induction of 27 kDa heat shock protein following cerebral ischemia in a rat model of ischemic tolerance. Brain Res., v.634, 235-44.

161. Kelley P.M., Aliperti G., Schlesinger M.J. (1980): In vitro synthesist of heat shock proteis by mRNAs from chicken embryo fibroblastes. J. Biol. Chem., v.255, 3230-3233.

162. Kelley P., Schlesinger M.J. (1982): Antibodies to two major chicken heat shock proteins crossreact with similar protein in widely divergent species. Mol. Cell Biol., v.2, 267-279.

163. Kennedy I.M., Burdon R.H., Leader D.P. (1984): Heat shock causes diverse changes in the posphorilation of the ribosomal proteins of mammalian cells. FEBS Lett., v. 169, 267273.

164. Kermer P., Klocker N., Bahr M. (1999): Neuronal death after brain injury. Cell Tissue Res. 298: 383-395.

165. Kiessling M., Dienel G. A., Jacewicz M., and Pulsinelli W.A. (1986): Protein synthesis in postishemic rat brain: a two-dimensional electrophoretic analysis. J. Cereb. Blood Flow Metab., 6, 642-649.СПИСОК ЛИТЕРАТУРЫ

166. Kim Т.A., Lim J., Ota S., et al. (1998): NRP/B, a novel nuclear matrix protein, associates with p. 110 (RB) and is involved in neuronal differentiation. J. Cell Biol, v. 141, 553-66. j

167. Kim Y.S., Hong K.S., Seong Y.S., et al. (1994): Phosphorylation and activation of mitogen-activation protein kinase by kainic acid-induced seizure in rat hippocampus. Biochem. Biophys. Res. Commun., v.202, 1163-1168.

168. Kimeldorf D.J. and Nunt E.L. (1965): Ionizing radiation: neural function and behavior, Academic Press, New York.

169. Klassen N.L., Walker P.R., Ross С. K., Cygler J., and Lach B. (1993): Two-stage cell shrinkage and the OER for radiation-induced apoptosis of rat thymocytes. Int. J. RadBiol., 64, 571-581.

170. Koenig J. (1972): Ribonucleic acid of neurons system. In: The structure and function of neurons system. Ed. Bourne N.Y.L.: Acad. Press, v.4, 179-214.

171. Kolder C., Chan-Paley V., Wu I.J. (1984): Septal neurons containing glutamic decarboxilase acid immunoreactivity project to the hippocampal region in the brain. Anat. Embriol., v. 169, 35-39.

172. Konecki J. (1977): Some problems of structure and function of motoneurones of the spinal under conditions of intensive motor activity. Folia Histochem. Cytochem., v. 15, 95107.

173. Korn E.D. (1982): Actin polymerization and its regulation by proteins from nonmuscle cells, Physiol. Rev., v. 62, 672-737.

174. Krilovicz B.L., Glotzbach S.F., Heller H.C. (1988): Neuronal activity during sleep and complete bouts of hibernation. Am. J. Physiol., v. 255, R1008-1019.

175. Krolak J.M., McClain D., Snyder S.L., Fuchs P., and Minton K.W. (1989): 18SСПИСОК ЛИТЕРАТУРЫribosomal RNA is degraded during ribosome maturation in irradiated HeLa cells. Radial. Res., 118, 330-340.

176. Larson D.E., Zanradka P., and Sells B.H. (1990): Control points in eucaryotic ribosome biogenesis. Biochem. Cell Biol., 69, 5-22.

177. Lauterborn J., Isackson P., and White J; (1990): Seizures, neuropeptide regulation, andimRNA expression in the hippocampus. Prog. Brain Res., 83: 371-390.

178. Lawrence J.B., Singer R.H. (1986): Intracellular localization of messenger RNAs for cytoskeletal proteins. Cell, v.45(3), 407-415.

179. Leard L.E., Macdonald E.S., Heller H.C., KildufF T.S. (1994): Ontogeny of photic-induced c-fos mRNA expression in rat suprachiasmatic nuclei. Neuroreport, 20, 5(18), 2683-2687.

180. Lee Y.J., Hou Z.Z., Curefty L., et al. (1992): Heat-resistant variants of the Chinese hamster ovary cell: alteration of cellular structure and expression of vimentin. J Cell Physiol. ,v,151, 138-146.

181. Lewis M.J., Pelham H.R. (1985): Involvement of ATP in the nuclear and nucleolar functions of the 70 kDa heat shock protein. EMBO J., v. 4, 3137-3143.

182. Lian S.L. (1989): Ultrastructural changes in the frontal cortex of mice after irradiation: a study of dose-rate and field size effect. Kao Hsiung I Hsueh Ко Hsueh Tsa Chin, v. 5, 96106.

183. Liao J., Omary M.B. (1996): 14-3-proteins associate with phosphorilyted simple epithelial keratins during cell cycle progression and act as a solubility cofactor. J Cell Biol., v.133, 345-357.

184. Lim J.J., Feramisco J.R. (1981): Disruption of the intermediate filaments in fibroblasts through the microinjection of specific monoclonal antibody. Ce//, v. 24, 185-191.

185. Lim L. (1977): Regulation of ribosoijnic acid metabolism in the developing brain. Biochemical correlation of Brain Structure and Function. Ed. Davidson A.N.,: Acad. Press, L-N-Y.-San Fran., 15-42.

186. Lindquist S. (1986): The heat shock response, Ann. Rev. Biochem, 55, 1151-1191.

187. Lindquist S. and Craig E.A. (1988): The heat shock protein. Ann. Rev. Genet, 22, 631677.

188. Lino Т., Katsura M., Kuriyama K. (1992): Protective effect of vinconate on ischemia-induced neuronal damage in therat hippocampus. Eur J. Pharmacol., 2; 224, 117-124.СПИСОК ЛИТЕРАТУРЫ

189. Lipton P., Raley-Susman K.M. (1999): Autoradiographic measurements of protein synthesis in hippocampal slices from rats and guinea pigs. Methods, 18:127-43.

190. Litman P., Barg J., Ginzburg I. (1994), Microtubules are involved in the licalization on tau mRNA in primary neuronal cultures. Neuron., v. 13, 1463-74.

191. Little J.B. (1990): Low-dose radiation effects: interaction and synergism. Health Physics, 59,49-55.

192. Lorente de No. (1934): Studies on the structure of the cerebral cortex. II. Combination of the study of the Amnionic system. J. Physiol. Neurol., 46, 113-117.

193. MacDonald P.M., Struhl G. (1988): cis-acting sequences responsible for anterior localization of bicoid mRNA in Drosophila embryos. Nature (London), 336(6199): 595598.

194. Magnusson K., Wieloch T. (1989): Impairment of protein ubiquitination may cause delayed neuronal death. Neurosci Lett., 96: 264-70.

195. Malhotra A., Harvey S.C. (1994): A quanvitative mode of the Escherichia coli 16S RNA in the 30S ribosome subunit. J. Mol. Biol., v.240, 308-340.

196. Mamalaki A., Bouton E., Hurel E., et al. (1995): The BM88 antigene, a novel neuron-specific molecule, enhances the differentiation of mouse neuroblastoma cells. J. Biol. Chem., v.270, 14201-14208.

197. Marzonki A., Leverque J-P., Rebond A.M. (1990): Modification of the acidic ribosomal proteins after elongation factor 2 binding to rat liver ribosomes and during translocation. Biophys. Biochem. Acta, v. 1048, 238-244.

198. Matson M.P., Kater S.B. (1989): Development and selective neurodegeneration in cell cultures from different hippocampal regions. Brain Res., v.490, 110-25.

199. Matsumoto G., Hikoichi Sahai (1979): Microtubules inside the plasma membrane of squid giant axons and their possible physiological function. J. Membrane Biol,, v.50, 1-14.

200. Mayrand S., Pederson T. (1983): Heat shock alters nuclear ribonucleoprotein assambly in Drosophyla cells. Cell. Biol., v.3, 161-171.

201. McAlister L., Finkelstein D.W. (1980): Heat-shock proteins and thermal resistance of yeast. BBRC, v.93, 819-824

202. McLean W.H.I, et al. (1996): Loss of plectin causes epidermolysis bullosa with muscular dystrophy: cDNA cloning and genomic organization. Genes Dev., v. 10, 1724-1725.

203. McMullin T.W., Hallberg R.L. (1986)j Effect of heat shock on ribosome structure: appearance of new ribosome-associated protein. Mol. Cell Biol, v. 6, 2527-35.

204. Meldrum B.S., Evans M.C., Swan J.H., Simon R.P. (1987): Protection against hypoxic/ischemic brain damage with exitatory amino acid antagonists. Med. Biol, v.65, v 2/3, 153-157.

205. Melloni R.H., Hemmenclunger L.M., Hamos J.E., DeGennaro L.J. (1993): Synapsin I gene expression in the adult rat brain with comparative analysis of mRNA and protein in the hippocampus. J. Comp. Neurol., v.22, 507-520.

206. Messing A. (1982): Cholinergetic agonist induced down regulation of neuronal a-bungarotoxin receptors. Brain Res., v.232, 479-84.

207. Metafora S., Persice H., Ferraituolo R, Ginditta A. (1977): On the- machanism of electroscock induced inhibition of protein synthesis in rabbit cerebral cortex. J. Neurochem., v.28, 1335-1346.

208. Miyamoto E. (1990): A study on the role and mechanism of intracellular Ca2+ in the central nervous system. Nippon Yakurigaku Zasshi, v.96, 141-152.

209. Miles M.F., Diaz J.E., DeGuzman V. (1992): Ethanol-responsive gene expression in neural cell cultures. Biochim Biopys Acta, 14, 1138, 4, 268-274.

210. Miller J.D., Cao V.H., Heller H.C. (1994): Thermal effects on neuronal activity in suprachiasmatic nuclei of hibernators and nonhibernators. Am. J. Physiol., v. 166, R1259-1266.

211. Moazed D., Van Stolk B.J. (1986): Douthwaite S., Noller H.F., Interconvertion of active and inactive 30S ribosomal subunits is accompaied by a confor mational change in the decoding region of 16S rRNA. JMB, v.191, 483-493.СПИСОК ЛИТЕРАТУРЫ

212. Morimoto R.I., Tissieres A., Georgopoulos С. (1994): The biology of heat shocki 8protein and molecular chaperones! Cold Spjring Harbor Press, New York

213. Morris B.J., Feasey K.J., Bruggencate p., et al. (1988): Electrical stimulation in vivo increases the expression of proenkephalin mRNA and decreases the expresion of prodynorphin mRNA in rat hippocampal granule cells. PNAS USA, v.85, 3226-3230.

214. Moss R., Pryme I.F., Vedeler A. (1994): Free, cytoskeletal-bound and membrane bound polysomes isolated from MPC-11 and Krebs II sacites cells differ in their complement of poly (A) binding proteins. Mol. CellBiochem., v. 131, 131-139.

215. Muench D.G., Wu Y., Coughlan S.J., Okita T.W. (1998): Evidence for a cytoskeleton-associated binding site involved in prolamine mRNA localization to the protein bodies inrice endosperm tissue. Plant Physiol., v. 116j, 559-69.i

216. Nabeshima Y.I., Tsurugi K., Ogata KL (1975): Prefential biosynthesis of ribosomal structural proteins by free and loosely bound polysomes from regenerating rat liver. Biochim Biophys Acta, v.414, 30-43.

217. Nakayasu H., Ueda K. (1985): Association of repidly-labelled RNAs with actin in nuclear matrix from mouse L5178Y cells. Exp. Cell Res., v. 160, 319-330.

218. Nakayasu H., Ueda K. (1984): Small nuclear RNA-protein complex anchors on the actin filaments in bovine lymphocyte nuclear matrix. Cell Struc. and Fund., v.9, 317-325.

219. Namba H., Irei Т., Fukushi K., et al. (1996): Time courses of changes in cerebral blood flow and blood-brain barrier integrity by focal proton radiation in the rat. Neurol Res., v. 18, 83-86.i

220. Naves F.J., Huerta J.J., et al. (1996): Distribution of immunoreactiviry for cytoskeletal (microtubule, microtubule-assosiated, and neurofilament) proteins in adult human dorsal root ganglion. Anat. Rec., v.244, 246-256.

221. Nelson E.H., Winkler M.M. (1986): Regulation of mRNA entry into polysomes. J Biol. Chem.,\. 267, 11501-115.

222. Nelson R.J., Ziegelhoffer Т., Nicolet C., et al. (1992): The translation machinery and 70 kD heat shock protein cooperate in protein synthesis. Cell, v. 71, 97-105.

223. Nickerson J. A., Penman S. (1992): Localization of nuclear matrix core filament proteins at interphase and mitosis. Cell Biol. Int. Rep., v. 16 811-26.СПИСОК ЛИТЕРАТУРЫ

224. Nilsson G.E., Lutz P.L. (1993): Role of GAB A in hypoxia tolerance, metabolic depression and hibertnation-possible links to neurotransmitter evolution. Comp. Biochem Physiol C, 105(3)329-336.

225. Nitatori Т., Sato N., Waguri S., et al. (1995): Delayed neuronal death in the CA1 pyramidal cell laeyr of the gerbil hippocampus following transient ischemia is apoptosis. J. Neurosci, 15 (2), 1001-1011.

226. Nixon R.A., Sihag R.K. (1991): Neurofilament phosphorylation: a new look at regulation and function. Trends Neurosci., v.14, 501-6.

227. Noble N.D., Broun Th.H., Peacock J.H. (1976): Regulation of acetylcholine receptor levels by cholinergic agonist in mouse muscle cultures. PNAS USA, v.75, 3488-92

228. Noga M., Hayashi Т., Tanaka J. (1997): Gene expressions ofiibiquitin and hsp70 following focal ischaemia in rat brain. Neuroreport, v. 8(5), 1239-41.

229. Nowak T S., Ikeda J., Nakajama T. (1990): 70-kDa heat shock protein and c-fos gene expression after transient ischemia, Stroke, 21, 11, Suppl. Ill, 107-111.

230. Nürnberger F., Lee Т.F., Jourdan M.L., Wang L.C. (1991): Seasonal changes in methionine-enkephalin immunoreactivity in the brain of a hibernator, Spermophilus columbianus. Brain Res., v.547, 115-121.

231. Nürnberger F., Krug L., Ohwatani N., Pleschka K. (1997): Adrenergic signal transduction in the brainstem of euthermic and hibernating European hamsters. Ann. NY Acad. Sei., v.813, 705-711.

232. Nürnberger F., Pleschka К., Masson-Pevet P. (1997): The somatostatin system of the brain and hibernation in the European hamsters (Cricetus cricetus). Cell Tissue Res., v.288, 441-447.

233. Ochs R., Lischwe M., O'Leuvy P., Busch H. (1983): Localization of nuclear phosphoproteins B23 and C23 during mitosis, Exptl. Cell Res., v. 146, 139-149.

234. O'Hara B.F., Watson F.L., Srere H.K., et al. (1999): Gene expression in the brain across the hibernation cycle. J. Neurosci., v. 19, 3781-3790.СПИСОК ЛИТЕРАТУРЫ

235. Okada M., Miyake Т., Kitamura Т., Kawasaki K., Mizuxhima Y. (1994): Anti-ubiquitin immunoreactivity associates with pyramidal cell death induced by intraventricular infusion of leupeptin in rat hippocampus. Neurosci Цes., 19, 59-66.

236. Oliver J.M. and Berlin R.D. (1982): Mechanisms that regulate the structural and functional architecture of cell surfaces. Int. Rev. ofCyt., 74, 55-94.

237. Ornellas M R., Jones D.A. (1987): Distribution of ribosomal material in incubated and electrically stimulated cerebral slices. J. Neurochem, v. 19, 791-800.

238. Oshita Т., Kamada Т., Endo Y., Natori Y. (1984): Heterogenety of free valine pools for protein synthesis on free and membrane-bound polysomes in rat liver. J. Biochem. (Tokyo), v.93, 651-657.

239. Padgett R.A., Grabowski P.J., Konarska M.M., et al. (1986): Splicing of messenger RNA precursors. Ann. Rev. Biochem., 55, 119-150.

240. Passarelli F., Angeletti В., Orru D., Orzi F. (1994): Ambrosio E. Effects of electroconvulsive shock on the levels of hsp70 and hsp73 mRNA in the rat brain. Neurosci Lett., v.177, 147-50.

241. Patel S., Meldrum B.S., Collins J.F. (1986): Distribution of 3H.-kainic acid binding sites in the rat brain: in vivo and in vitro receptor autoradiography. Neurosci Lett, 70(3):301-307.

242. Pederson T. (1983): Nucleolar RNA-protein interactions and messenger RNA processing. J.Cell. Biol., 97, 1321-3126.

243. Peimer S.I., Dudkin A.O. and Swerdlov A.G. (1986): Response of hippocampal pacemaker-like neurons to low doses of ionizing radiation. Int. J. Radial Biol., 49, 597600.СПИСОК ЛИТЕРАТУРЫ

244. Pekkala D., Silver J.С. (1987): Heat-shock-induced changes in the posphorilation of ribosomal and ribosome-associated proteins in the filamentous fungus Achlya ambisexualis. Exp. Cell Res., v.168, 325-37.

245. Pelham H.R.B. (1986): Speculations on the functions of the major heat shock and glucoseregulated proteins. Cell, v. 46, 959-961.

246. Pellmar T.C., Schauer D.A. and Zeman G.H. (1990): Time and dose-dependent changes in neuronal activity produced by X radiation in brain slices. Radiat. Res., 122, 209214.

247. Pevzner L.Z. (1981): Topochemical aspects of nucleic and protein metabolism within the neuron-neuroglia unit of the hypothalamic supraoptic nuoleus. Americ.J.Anat. v. 160, 473479.

248. Pinol-Roma S., Dreyfuss G. Shutting of pre-mRNA binding proteins between nucleus and cytoplasm. Nature, 355 (6362), 730-732.

249. Pisu M.B., Scherini E., Bernocchi 0. (1998): lmmunocytochemical changes of cytoskeleton components and calmodulin in the frog cerebellum and optic tectum during hibernation. JChem Neuroanat., 15: 63-73.

250. Plumier J.C., Armstrong J.N., Landry J., Babity J.M., Robertson H.A., Currie R.W. (1996): Expression of the 27,000 mol. wt heat shock protein following kainic acid-induced status epilepticus in the rat. Neuroscience, 75: 849-56

251. Pollard T.D., Selden S.Ch., Maupin P. (1984): Interaction of actin filamentes with microtubules, J. Cell Biol., v.99, suppl. 2, 33s-37s.

252. Popov V.I. and Bocharova L.S. (1992): Hibernation-induced structural changes in synaptic contacts between mossy fibres and hippocampal pyramidal neurons. Neuroscience, 48 :53-62.

253. Popov V.I., Bocharova L.S. and Bragín A.G. (1992): Repeated changes of dendritic morphology in the hippocampus of ground squirrels in the course of hibernation. Neuroscience, 48, 45-51.cnncoK jim 'EPATYPH

254. Portier M.M. (1992): Neuronal cytoskel ;ton: structural, functional and dynamic aspects.Rev. Neurol (Paris), v. 148, 1-19.

255. Prasad K.N. (1985): Differentiation of neuroblastoma cells in culture. Biol. Rev., v.50, 129-265.

256. Quezzani S., Tramu G., Magoul R. (1999): Neuronal activity in the mediobasal hypothalamus of hibernating jerboas. Neurosci Lett., v.260, 13-16,

257. Raley-Susman K.M., Lipton P. (1990): In vitro schemia and protein synthesis in the rat hippocampal slice: the role of calcium and NMDA receptor activation Brain Res., v.515, nl/2. 27-38.

258. Raley-Susman K.M., Murata J. (1995); Time course of protein changes following in vitro ischemia in the rat hippocampal slice. Brain Res., 1995 Oct 2; 694(1-2): 94-102

259. Ramapogal S. (1990): Subcellular distribution of ribosome proteins in Dictyostellium discoideum. Biochem Cell Biol., v.68, 839-845.

260. Reiter T., Penman S. (1983): "Promt" heat shock proteins: translationally regulated synthesis of new proteins assiciated with the nuclear matrix- intermediate filaments as an early responce to heat shock. FN AS USA, v. 80, 4737-4741.

261. Riederer B.M. (1995): Differential phosphorilation of MAP IB during postnataldevelopment of the cat brain. J. Neurocytol., v.24, 45-54.

262. Riederer B., Matus A. (1985): Differential expression of distinct microtubule-assotiated proteins during brain development. PNAS USA, v. 82, 6006-6009.

263. Riederer B.M., Porchet R., Marugg R.A. (1996): Differential expression andimodification of neurofilament triplet proteins during cat cerebellar development. J. Comp. Neurol, v.364, 704-17.

264. Rigler R. (1966): Microfluorometric characterization of intracellular nucleic acids and nucleoproteins by acridine orange. Acta Physiol. Scand, 76, 5-127.

265. Roniller D.G., Mc Keen C., Taylor S.J., Golden P. (1988): Hormonal regulation on insulin receptor gene expression. J.Biol. Chem., v.263, 165-90.

266. Sadis S., Hickey E., Weber L.A. (1988): Effect of heat shock on RNA mrtabolism in HeLa cells. J. Cell. Physiol, v. 135, 377-386.

267. Sado T., Kamisaki H., Ikarashu Y., and Kubo E. (1988): Immidiate and long-term effects of radiation on the immune system of specific-pathogen-free mice. Int. J. Rad. Biol, 53, 177-187.

268. Saenz-Robles M.T., Remacha M., Vilella M.D., Zinker S., Balesta J.P.G. (1990): The acidic ribosomal proteins as regulators of the eukaryotic ribosomal activity. Biophys Biochem Acta., v. 1050, 51-55.

269. Saido T.C., Tawashima S., Tani E., Ybkota M. (1997): Up- and down-regulation of calpain inhibitor polypeptide, calpastatin, in postischemic hippocampus. Neurosci Lett., v. 227, 75-78.

270. Saito N., Kawai K., Nowak T.S. (1995): Reexpression of developmental^ regulated NAP2c mRNA after ishemiaxolocalization with hsp72 mRNA in vulnerable neurons J. Cereh. BloodFlouMetab., v. 15, 205-215.

271. Samarina O.P., Krichevskaya A.A. (1981): Nuclear 30S RNP particles. The Cell Nucleus. Ed. H. Bursh. NY. Acad. Press, v.9, 1-48.

272. Sandler R., Smith A.D. (1991): Coexistence of GABA and glutamate in mossy fiber termals of the primate hippocampus: an ultrastructural study. Comp. Neurol, v.303, n2, 177-192.

273. Sanger J.W., Sanger J.M., Kreis T.E., Jockusch B.M. (1980): Reversible translocation of cytoplasmic actin into the nucleus caused by dimetyl sulfoxide. PNAS USA, v. 77, 52685272.

274. Sanz O., Estrada A., Ferrer I., Planas A.M. (1997): Differential cellular distribution and dynamics of HSP70, cyclooxygenase-2, and c-Fos in the rat brain after transient focal ischemia or kainic acid. Neuroscience, 1997 Sep; 80(1): 221-232.

275. Schiman A., Atha T., Aquinaldo A.M., et al. (1992): Mapping the three dimensional locations of ribosomal RNA and proteins. Biochemie, v. 74, 307-317.СПИСОК ЛИТЕРАТУРЫ

276. Schmidt-Zachmann M.S., Franke W.W. (1988): DNA cloning and amino acid sequence determination of a major constituent protein of mammalian nucleoli Chromosoma, 96, 417426.

277. Schwartz R.D., Keller K.I. (1983): Nicotinic cholinergic receptor binding sites in thebrain regulation in vivo. Science, v.220, 214-16.

278. Sharp F.R., Massa S.M., Swanson R.A. (1999): Heat-shock protein protectioin, TINS, v.22, 97-99.

279. Shestakova E.A., Motuz L.P., Minin A.A., Gavrilova L.P. (1993): Study of localization of the protein-synthesizing machinery along actin filament bundles. Cell Biol. Int., 17, 409416.I

280. Semmel M., Daune M. (1967): Complexes of basic dyes with RNA. Biophys Biochem Acta, v. 145, 561-576. j

281. Simon R.G., Klein W.L. (1981): Specificity of muscarinic acetylcholine receptor activity. J. Neurochem., v. 37, 1099-1108.

282. Sims N.R. (1995): Calcium, energy metabolism and the development of selective neuronal loss following short-term cerebral ischemia. Metab Brain Dis., v. 10, 191-217.

283. Singer R.H. (1992): The cytoskeleton and mRNA localization. Curr. Opin. Cell Biol., v.4, 15-21. !

284. Singer R.H., Langevin G.L., Lawrence J.B. (1989): Ultrastructural visualization of cytoskeletal mRNAs and their associated proteins using double-label in situ hybridization. J Cell Biol, 108(6): 2343-2353.

285. Smith H.C. and Berezney R. (1982): Nuclear matrix-bound deoxyribonucleic acid sunthesis: an in vitro system. Biochemistry, 21, 6751-6761.

286. Smith M.A., Makino S., Kvetnansky R., Post R.M. (1995): Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus, J. Neurosci., 15, 3 1, 1768-1777.

287. Soborio V.L., Pong S.S., Koch G. (1974): Selective and reversible inhibition of protein synthesis in mammalian cells. J. MoI.Biol,. 85: 195-211.

288. Soltysik-Espanola M., Rogers R.A., Jiang S., et al. (1999): Characterization of mayven, a novel actin-binding protein predominantly expressed in brain. Mol. Biol. Cell, v. 10, 236175.

289. Spector D.L., Ochs R.L., Busch H. (1984): Silver staining, immunofluorescence, and immunoelectron microscopic localization of nuclear phosphoproteins B23 and C23. Chromosoma, v.9, 139-148.

290. Stacchiotti A., Schiaffonati L., Tiberio L., Rodella L., Bianchi R. (1997): Constitutive expression of heat shock proteins 70 and 90 in rat cerebellum. Eur J Histochem, 41(2): 127-132.

291. Stamp Y.A., Semba K. (1995): Extent of colocalization of serotonin and GAB A in theneurons of the rat raphe nuclei. Brain Res., y.677. nl, 39-49).j

292. Stern A.S., Powers T., Changchien L.M., Noller H. (1989): RNA-proteins interactions in 30S ribosomal subunits. Folding and function of 16S rRNA. Science, v.244, 783-790.

293. Steward O., Banker G.A. (1992): Getting the messge from the gene to the synapse: sorting and intracellular transport ofRNA in neurons. TINS, v.15. 180-187.

294. Stoykova A.S., Dubov K.P., Dabeva M.D., Hadjiolov A.A. (1983): Different rates of synthesis and turnover of ribosomal RNA in rat brain and liver. J. Neurochem. v.41, 942947.

295. Sulzer D., Joyce MP., Lin L., Geldwert D., et al. (1998): Dopamine neurons make glutamatergic synapses in vitro. Neurosci, vjl8, n.12, 4588-4602.

296. Sundell C.L., Singer RH. (1990): Actin mRNA localizes in the absence of protein synthesis. J. Cell Biol., 111(6 Pt 1): 2397-2403.

297. Suryanarayana T., Burma DP. (1975): Effect of intercalating agents on the structure of the ribosome. BBRC, v.713.121 СПИСОК ЛИТЕРАТУРЫ

298. Sztriha L, Loo F., Szerdahelyi P. (1985): Accumulation of calcium in the rai hippocampus during kainik acid seizures. Brain Res., 360(1-2): 51-57.

299. Tanimoto M. and Okada Y. (1987): The protective effect of hypothermia on hippocampal slices from guinea pig during deprivation of oxygen and glucose. Brain Res., 417(2): 239-246

300. Terra F., Lesort M., Dussartre C., et al. (1996): Phosphorylated neurofilament expression and resistance to kainate toxicity. Brain Res. Bull, v.41, 231-5.

301. Tolliver J.M. and Pellmar T.C. (1987): jlonizing radiation alters neuronal excitability inihippocampal slices of the guinea pig. Radial. Res., 112, 555-563.

302. Toyoshima I., Yamamoto A., Satare M. (1988): Processing of heurofilamenr proteins from perikaryal to axonal type. Neurochem. Res., v. 13, 621-624.

303. Traganos F., Crissman H.A., Darzynkiewicz Z. (1988): Scaning with pyronin Y detects changes in conformation of RNA during mitosis and hyperthermia of CHO cells. Exp. Cell Res., v. 179, 535-544.

304. Traub P., Bauer C., Harting R., Grub S., Stahl J. (): Colocalization of single ribosomes with intermediate filaments in puromycin-treated and serum-starved mouse embryo fibroblasts. Biol. Cell., v.90, 319-337.

305. Traub P., Mother E., Shoeman R.L., Schroder R., Scherbarth A. (1992): Binding of nucleic acids to intermediate filaments of the vimentin type and their effects on filament formation and stability. J. Biomol Struct Dyn., v. 10, 505-531.I

306. Uz Т., Giusti P., Kharlamov A., Manev ¡H. (1996): Protective effect of melatonin aganst hippocampal DNA damage induced by intraperitonial administration of kainate to rats. Neuroscience, 73, 631-636.

307. Van Dongen G., Geilenkirchen W.L.M., van Rijn J., van Wijk R. (1986): Increase of thermoresistance after growth stimulation of resting Reuber H35 hepatoma, cells Exp. Cell Res., 166, 427-441. |

308. Vedeler A., Pryme J.F., Hesketh J.E. (1990): Insulin and step-up conditions cause a redistribution of polysomes amond free, cytoskeletal-bound and membrane-bound fractions in Krebs II ascites cells. Cell Biol Int Rep., 1.14, 211-218.

309. Velazques J.M., Domenico B.J., Lindquist S.l. (1980): Intracellular localization of heat shock proteins in Drosophila. Cell, v. 20, 679-689.

310. Veyrune J.L., Campbell G.P., Wiseman J., et al. (1996): A localisation signal in the 3' untranslated region of c-myc mRNA targets c-myc mRNA and beta-globin reporter sequences to the perinuclear cytoplasm. J.CellSci., 109 (Pt 6), 1185-1194.

311. Vesco C., Ginditta A. (1968): Disaggregation of brain polysoms induced by electroconvulsive treatment. J. Neurochem.,, v. 15, 81-86.

312. Vignali G., Niclas J., Sprocati M.T.j Vale R.D., Sirtori C., Navone F. (1996): Differential expression of ubiquitous and neuronal kinesin heavy chains duringdifferentiation of human neuroblastoma andPC12 cells. Eur JNeurosci., 8(3): 536-544.

313. Vignola C, Fenoglio C, Scherini E, Bernocchi G. (1995): The cerebral neurons of Helix aspersa during hibernation. Changes in the cytochemical detection of calmodulin, cytoskeletal components and phosphatases. Tissue and Cell, 27(2): 185-196.

314. Vizi E.S., Kiss J.P. (1998): N euro chemistry and pharmacology of the major hippocampal transmittersystem: synaptic and nonsynaptic interactions. Hippocampus, v.8, 566-607.

315. Wachsfeger P.R., Coss R.A. (1993): Alterations in nuclear matrix ultrastructure of G1 mammalian calls following heat shock: resihless section electron microscopy, biochemical, and immunnofluorescence studies. J. Cell Physiol., v. 155, 615-634.

316. Waechter C.I., Schmidt I.W., Callerall W.A. (1983): Glycosylation is required for maintenance of functional sodium channals in neuroblastoma cells. ,/. Biol. Chem., v. 258, 5117-5123.

317. Wallace R.B., Kaplan R.F., Werboff J. (1976): Behavioral correlates of focal hippocampal x-irradiation in rat. Exp. Brain Res., v. 24, 343-349.

318. Walters B.B., Matus A.I. (1975): Tubulin in postynaptic junctional lattice. Nature (London), 257(5526): 496-498.

319. WanderWaal R., Thampy G., Wright W.D., Roti Roti J.L. (1996): Heat-inducedmodifications in the association of specific v. 145, 746-753.proteins with the nuclear matrix. Radiai. Res.,

320. Wang S., Hamberger A., Ding M., Haglind K.G. (1992): In vivo activation of kainate receptors induced dephosphorylation of the heavy neurofilament subunit. J. Neurochem, v.59., 1975-1978.

321. Warner JR. (1990): The nucleolus and ribosome formation. Current Opinion in Cell Biology, 2, 521-527.

322. Waiters R.L., Brizgus L.M., Shama R, Roti Roti J.L. (1986): Heat shock results in an increase of nuclear matrix protein mass in HeLa cells. Int. J. Radial. Biol, v.50, 253-268.

323. Wek R.C. Elf-2 kinases: regulators of general and gene-specific translarion initiation, TIBS, 19, 481-486.

324. Welch W.J. (1993): Heat shock rpoteins functioning as molecular chaperones: their roles in normal and stressed cells. Philos Trans R. Soc Lond. B. Biol Sci., v. 339, 327-333.

325. Welch W.J., Brown C.R (1996): Influence of molecular and chemical chaperones on protein folding. Cell Stress Chaperones, 1(2): 109-115.

326. Welch W.J., Fersmisco J.R. (1985): Disruption of the three cytoskeletal networks in mammalian cells does not affect transcription, translation, or protein translocation changes induced by heat shock. Mol Cell Biol., v.5, ,'1571-1581.

327. Westrum L.E., Grey E.G. (1977): Mictotubule associated with postsynaptic «thickenings». J. Neurocytol., v.6, 505-518.

328. Wheller K.T. and Wierowski I.V. (1983): DNA repair kinetics in irradiated undifferentiated and terminally diffetentiated cells. Radiat. Environ. Biophys.% 22, 3-19.

329. White B.C., Grossman L.I., O'Neil B.J., DeCracia D.J., Neumar R.W., Rafold J.A. and Krause G.S. (1996): Global brain ischemia and reperfusion. Ann. Emerg. Med., 27, 588594.

330. White J.D., Gall C.M. (1987): Differential regulation of neuropeptide and proto-oncogene mRNA content in the hippocampus following reccurent seizures. Mol. Brain Res. v.3, 21-29.

331. Willis J.S. (1979): Hibernation cellular aspects. Ann. Rev. Physiol., v.41, 275-286.

332. Wilson G.M., Vasa M.Z., Deeley R.G. (1998): Stabilization and cytoskeletal-association of LDL receptor mRNA amediated by distinct domains in its 3' untranslated region. J. Lipid Res., v.39, 1025-1032.

333. Wiseman J.W., Glover L.A., Hesketh J.E. (1997): Exidence for a localisation signal in the 3' untranslated region from vimentin mRNA. Int. J. Cell Biol., v.29, 1013-1020.

334. Wolitzky W.A., Fambrough D M. (1986): Regulation of the (Na+-K+) ATP-ase in cultured chick skeletal muscle. Modulation of expression by the demand for ion transport. J. Biol. Chem., v.261, 9990-9999.

335. Wynter C.V.A. (1979): Persistence of altered RNA synthesis in rat cerebral cortex 12h after a single electroconvulsive shock. J. Neurochem., v.32, 495-504.

336. Yamagata K., Andreasson K.L., Kaufmann W.E., Barnes C.A., Worley P.F. (1993): Expression of a mitogen-inducible cyclooxygenase in brain neurins: regulation by synaptic activity and glucocorticoids, Neuron, 11, 2, 371-86.

337. Yamamoto K., Pellegrini M. (1990): Ribosome subunit ti ribosome ratios affect the synthesis of rRNA in Drosophila cells. Biochemistry, 29; 11029-11032.

338. Yang F., Demma M., Warren V., . Dharmawardhane S., Condeelis J. (1990):t.1.entification of an actin-binding protein from Dictyostelium as elongation factor la. Nature (London), 1990 Oct; 347(6292): 494-496.

339. Yang Y., Dowing J., Yu Q-C., et al. (1996): An essential cytoskeletal linker protein connecting actin microfilaments to intermediate filaments. Cell, v. 86, 655-665.

340. Yang Q., Wang S., Karlsson J.E., et al. (1995): Phosphorylated and non-phosphorylated neurofilament proteins: distribution in the rat hippocampus and erly changes after kainic acid induced seizures. J. Chem. Neuroanat., v.9., 217-228.

341. Yeung T.K., Germond C., Chen X., Wang Z. (1999): The mode of action of taxol: apoptosis at low concentration and necrosis at high concentration. BBRC, 263, 398-404.

342. Yisraeli J.K., Melton D A. (1988): The material mRNA Vgl is correctly localized following injection into Xenopus oocytes. Nature (London), 1988 Dec; 336(6199): 592-595.

343. Young R.W. (1987): Acute radiation syndroms. In: Military Radiobiology (J.J. Conrlin and R.I. Walker Eds.), Academic Press, New York, pp. 165-190.

344. Yorifuji H., Kanda K„ Sobue K., Hirakava N. (1989): Localization of 4.1 related proteins in cerebellar neurons. Eur. J. Biol., v.48, 104-115.СПИСОК ЛИ'125ЕРАТУРЫ

345. Yu L.C. and Cai Y.P. (1993): Effects cif opioid receptors antagonists administration to suprachiasmatic nucleus on hibernation od ground squrrels Cittelus dauricus. Comp. Biochem. Physiol. C, v. 104, 249-252.

346. Zambetti G., Schmidt W., Stein G., Stein J. (1985): Subcellular localization of histone messenger RNAs on cytoskeleton-associated free polysomes in HeLa S3 cells. J. Cell Physiol., v. 125, 345-353.

347. Zambetti G., Wilming L., Fey E.G., Stein J., Stein G. (1990): Differential association of membrane-bound and non-membrane-bound polysomes with the cytoskeleton. Exp. Cell Res., v. 191, 246-255. j

348. Zeitlin S., Parent A., Silverstein B. (1987): Efstratiadis A., Pre-mRNA splicing and the nucleolar matrix. Mol. md Cell Biol, v. 7, 111-120.

349. Zhang X., Boulton A.A., Yu P.H. (1996): Expression of heat shock protein-70 and limbic seuzure-induced neuronal death in the rat brain. Eur. J. Neurosci., v.8., 1432-1440.

350. Zhou B., Rabinovitch M. (1998): Microtubule involvement in translational regulation of fibronectin expression by light chain 3 of microtubule-associated protein 1 in vascular smooth muscle cells. Circ Res., v.83, 481-489.

351. Zigmond R.E., Bowers C.W. (1981): Influence of nerve activity on the macromolecular content of neurons and their effector organs;. Ann. Rev. Physiol., v. 43, 673-687.

352. Zoli M., Agnati L.F. (1996): Wiring and volume transmission in the central nervousisystem: the concept of closed and open synapses, Prog Neurobiol., 49(4): 363-80.